RGN and Pallister-Hall syndrome: In the context that sdr4-n is also fixed in GJ-weedy (Supplementary Data 7), it is ingenious that Rc, as a signature gene of weedy rice, may be the perfect one to reduce the risk of OsGF14h-induced PHS because not expressed at germination and seedling stages (Supplementary Fig. 11c), and whereby not counteract the ability of AG and ASD that modulated by OsGF14hWR04-6.