DEFA5 and Cowden disease: In addition, CD patients present Paneth cells abnormalities with a reduced expression of defensins.18–20 In the work of Alkaissi et al.,21 CD patients expressed less human α-defensin 5 (HD5) and AIEC strain LF82 translocation was increased in follicle-associated epithelium (FAE) of CD patients compared to non-IBD controls.