AIF1 and Zika virus infectious disease: While such cell-intrinsic expression features of GBM progenitors did not account for rates of ZIKV infection, we observed that HR GBM segregated both from MR GBM and HDB based on innate immune system signature genes such as human leucocyte antigen (HLA), CD74, IBA1, CD45 and CD11b, a marker of myeloid lineage (Figure 3C; Figure S3D).