For OS analysis, tumor location, serum ALP status, high peripheral lymphocyte count, serum uPA, and serum uPA activity resulted in a p-value of < 0.1 on univariate analysis, but multivariate analysis identified only serum ALP status (p = 0.024), high serum uPA (p = 0.008), and high serum uPA activity (p = 0.026) as risk factors. The gene discussed is PLAU; the disease is neoplasm.