As for FREM3, it was identified as a selection or GWAS signal of malaria in African populations in previous studies (Malaria Genomic Epidemiology et al. 2015; Ndila et al. 2018; Ravenhall et al. 2018; Choudhury et al. 2020), and the polymorphism of FREM3 was reported to be associated with differential susceptibility to severe malaria (Ndila et al. 2018; Choudhury et al. 2020). Here, FREM3 is linked to malaria.