More importantly, the defective microglia/macrophages in aging OxPC lesions further elevated transcripts including Cd74, H2-Aa, Fth1, Ftl1, and Spp1, which are also enriched in microglia/macrophages found in the chronically inflamed edge of slowly expanding MS brain lesions that associate with disease progression [7]. This evidence concerns the gene SPP1 and myeloid sarcoma.