In response to OxPCs, highly upregulated genes in microglia/macrophages include Apoc1, Cstd, Spp1, Lpl, Lgals1, Gpnmb, Anxa2, Lyz2, and Lipa; these genes are also elevated in microglia/macrophages enriched in MS lesions [6]. Here, SPP1 is linked to myeloid sarcoma.