Tumor-derived chemokines including CCL2, CCL3, CCL5, CCL15, CCL26, CXCL8, CXCL12 and CX3CL1 regulate the role of TAMs in tumors through CCR2, CCR1/5, CCR5, CCR1, CX3CR1, CXCR1/CXCR2, CXCR4 and CX3CR1, respectively, including: recruiting TAMs into the TME, modulating the M2 polarization of TAMs, enhancing the ability of TAMs to promote tumor angiogenesis and metastasis. This evidence concerns the gene CXCL12 and neoplasm.