Recently, Sanchez and colleagues [7] analyzed the mechanisms and patterns of somatic alterations in 10 common canonical pathways in different cancers using The Cancer Genome Atlas (TCGA) cohort: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3–Kinase/Akt, RTK–RAS, TGFβ signaling, p53, and β-catenin/Wnt. Here, TP53 is linked to cancer.