CLDN2 and inflammatory bowel disease: CEABAC10 mice allowed us to better appreciate the role of AIEC bacteria in inflammatory bowel diseases by demonstrating the involvement of the CEACAM6 glycoprotein in the ability of AIEC strains to adhere to the intestinal epithelium (Carvalho et al., 2009), and to better understand how this colonization modulated intestinal permeability, in particular by inducing the expression of pore-forming claudin 2 (Denizot et al., 2012).