VIL1 and Cowden disease: In this work, we describe a new mouse model named ‘Vill-hCC6’, in which CEACAM6 expression is driven by the mouse villin [also known as villin 1 (Vil1)] gene promoter, reproducing abnormal overexpression of the mannosylated human receptor CEACAM6 in the small intestine and allowing ileal colonization by AIEC bacteria, as observed in CD patients.