For patients with LDLR rs730882109, LDLR rs749038326, and APOB rs144467873 polymorphisms, we recommend aggressive correction of risk factors for CAD, including hypertension as well as insulin intolerance, and early prevention of the occurrence of CAD, especially AMI events, by conducting regular electrocardiograms, exercise stress tests, and so on. The gene discussed is APOB; the disease is hypertensive disorder.