LDLR and hyperlipidemia: There was an approximately 4-fold increased risk of hyperlipidemia in subjects with LDLR rs769446356 and AMI in individuals with the LDLR rs730882109 polymorphism, and a 2-fold increased risk of CAD in those with LDLR the rs749038326 polymorphism, compared with the groups without pathogenic variants of FH.