And as an antioxidant, VC could scavenge free radicals, enhance the activity of manganese superoxide dismutase (SOD) and glutathione peroxidase (GPx), improve the secretion and expression of adiponectin, and lower the levels of low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG) (32–35), which provided possible explanations for that VC could reduce the risk of NAFLD. The gene discussed is SOD1; the disease is metabolic dysfunction-associated steatotic liver disease.