The decreases in synaptic proteins (PSD95, synapsin 1, and synaptophysin) and autophagy-related proteins (LC3, P62, Pink1, and Parkin) observed in the wild-type and AD mice were not present after genomic silencing of PKR (Figures 7D,E, Supplementary Figure S6). Here, EIF2AK2 is linked to Alzheimer disease.