We specifically hypothesized that genes involved in apoptosis, disease pathways (Parkinson’s, Alzheimer’s, Huntington’s, ALS), Parkin-Ubiquitin proteasome degradation, MAPK signaling, and inflammatory pathways would be differentially expressed in young adult Pink1−/− rats compared to WT controls, and sex-specific differences would be present, regardless of genotype. Here, PINK1 is linked to Parkinson disease.