CD4 and neoplasm: To evaluate the in vivo anti-tumor activity of the CD4-IL15/IL15sushi CAR T cells, we developed a xenogeneic mouse model using NSG mice sub-lethally irradiated (2.0 Gy) and intravenously injected with 1.0x106 luciferase-expressing MOLM13 cells 24 hours later to induce measurable tumor formation.