Expression of miR-124a was decreased in RA synovial fibroblasts, and in a rat model of arthritis (adjuvant-induced), rats with overexpression of miR-124 (rat analogue of human miR-124a) showed reduced osteoclastogenesis and the expression levels of RANKL, integrin β1 and nuclear factor of activated T cells cytoplasmic 1 (NFATc1) (53, 54). Here, TNFSF11 is linked to rheumatoid arthritis.