In the present study, we examined the effects of a dysfunction in the glucocorticoid receptor (GRdim/dim) on hemodynamics, metabolic parameters, mitochondrial function, and inflammation during resuscitation from hemorrhagic shock (HS) in mice with pre-traumatic cigarette smoke (CS) exposure with the effects on lung function already published in a previous paper (17). This evidence concerns the gene NR3C1 and histiocytic sarcoma.