Regarding the importance of this pathway in regulating autoimmunity, our colleagues found reduction of inflammatory cytokines, reduced overall splenic cellularity, reduced spleen weight, and improvement in aberrant myeloproliferative phenotype in miR-146a-/-Traf6+/- mice, which manifested reduced levels of TRAF6 similar to WT (34). This evidence concerns the gene TRAF6 and Autoimmunity.