TGFB1 and breast carcinoma: In line with our aforementioned findings in ccRCCs, the increase of ST3GAL5 expression was observed in CD44hi/CD24lo breast cancer stem-like cells (CSCs), compared with non-CSC population (45), while the enzymatic activity of ST3GAL5 is required for TGF-β1-induced ZEB1-dependent epithelial-to-mesenchymal transition (46).