CD8A and neoplasm: Considering that Braun and colleague had assessed the cell density of CD8+ T cells in tumor center and margin of ccRCC by immunofluorescence staining, along with gene expression profiling of ccRCC samples by RNA-sequencing (32), we analyzed their above data and found that ST3GAL5 mRNA level was positively associated the density of both central and marginal CD8+ T cells in their ccRCC cohort (Figure 5C).