The nuclear acid recognition receptors, including retinoic acid-inducible gene I (RIG-I), melanoma differentiation-associated gene 5 (MDA5), Toll-like receptors (TLR3, 7, 8, and 9), and the cyclic GMP-AMP synthase–stimulator of interferon genes–tank-binding kinase 1 (cGAS-STING-TBK1) axis, have been directly related to the pathogenesis of various autoimmune diseases (4–9). The gene discussed is RIGI; the disease is autoimmune disease.