STING1 and Aicardi-Goutieres syndrome: In addition, it has also been reported that mice with mutations in three RNaseH2 enzyme complexes (RNaseH2 A, RNaseH2 B, and RNaseH2 C) exhibit increased IFN signaling and inflammation, and ultimately cause AGS-like symptoms (83).The failure of mutated RNaseH2 to degrade RNA/DNA hybrids led to the excessive activation of cGAS-STING signaling, which induced AGS.