The percentage of CD3+CD4+ T cells, CD45+CD3+CD4+CXCR5+ T cells and CD4/CD8 ratio in peripheral blood of patients with ulcerative colitis and crohn’s disease was significantly lower than that of healthy controls, while the percentage of CD3+CD8+ T cells and CD19+CD5+ B cells in peripheral blood of patients with ulcerative colitis and crohn’s disease was significantly higher than that of healthy controls (Figures 2A, B). This evidence concerns the gene CD8A and ulcerative colitis.