By reviewing the literature related to tumor progression and angiogenesis, 17 proteins were selected from the above 29 proteins for PRM analysis, which, namely ACE, ANGPT2, CCN1, CD34, GDF15, HTRA1, HTRA3, IFI16, IGFBP7, LAMA4, LAMC1, MRPS15, MYO1B, PLVAP, RPL34, RPL4, and RPL6 (Figures 2C, D). The gene discussed is HTRA1; the disease is neoplasm.