By reviewing the literature related to tumor progression and angiogenesis, 17 proteins were selected from the above 29 proteins for PRM analysis, which, namely ACE, ANGPT2, CCN1, CD34, GDF15, HTRA1, HTRA3, IFI16, IGFBP7, LAMA4, LAMC1, MRPS15, MYO1B, PLVAP, RPL34, RPL4, and RPL6 (Figures 2C, D). Here, GDF15 is linked to neoplasm.