By reviewing the literature related to tumor progression and angiogenesis, 17 proteins were selected from the above 29 proteins for PRM analysis, which, namely ACE, ANGPT2, CCN1, CD34, GDF15, HTRA1, HTRA3, IFI16, IGFBP7, LAMA4, LAMC1, MRPS15, MYO1B, PLVAP, RPL34, RPL4, and RPL6 (Figures 2C, D). This evidence concerns the gene HTRA3 and neoplasm.