CD4 and neoplasm: By evaluating the level of immune cells infiltration in the TME, we noticed two primary features: 1) executive lymphocytes of anti-tumour (such as CD4+ T cells, CD8+ T cells, NK cells, and NKT cells) responses presented immunosuppressive status which feedback-induced M1 to M2 macrophage polarization; 2) Pearson correlation coefficient analysis showed that the riskscore is negatively correlated with the Immunescore.