Despite the existence of multiple well-characterized colorectal-cancer-associated macrophage subgroups, including C1QC+ TAMs, SPP1+ TAMs, and FCN1+ TAMs (32, 68, 69), we identified a kind of tumor-resident FOLR2+ LYVE1+ macrophage subgroup in colorectal cancer. The gene discussed is SPP1; the disease is colorectal cancer.