Statistically significant differences were observed in the lower levels of C3, C4 and platelets in B2-CIC-positive patients with isolated thrombotic APS compared to the negative patients as well as in the higher prevalence of thrombocytopenia only when patients were differentiated according to the positivity for B2-CIC (Figure 4; Table 3). This evidence concerns the gene C3 and autoimmune polyendocrinopathy.