C4A and autoimmune polyendocrinopathy: The comparison of B2-CIC-positive patients with isolated thrombotic APS (as well as patients with total thrombotic APS) and B2-CIC-positive patients with isolated gestational morbidity confirmed that patients with thrombotic manifestations and positive for B2-CIC had lower levels of C3, C4 and platelets as well as an increased incidence of thrombocytopenia and triple positivity compared to patients with obstetric APS.