The comparison of B2-CIC-positive patients with isolated thrombotic APS (as well as patients with total thrombotic APS) and B2-CIC-positive patients with isolated gestational morbidity confirmed that patients with thrombotic manifestations and positive for B2-CIC had lower levels of C3, C4 and platelets as well as an increased incidence of thrombocytopenia and triple positivity compared to patients with obstetric APS. This evidence concerns the gene C3 and autoimmune polyendocrinopathy.