In ovarian cancer which has a high immunosuppressive tumor environment (8, 49), the use of Muc16ecto specific CAR T cells modified to secrete IL-12 against ovarian cancer cells demonstrated by Koneru and colleagues (50) greater proliferation and increased IFN-γ secretion compared to CAR-T cells without IL-12. The gene discussed is IFNG; the disease is ovarian carcinoma.