LGR5 and malignant colon neoplasm: MicroRNA (miR)-363 suppressed the translation of GATA binding protein 6 (GATA6), which functioned as a transcriptional factor to induce REG4 and leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) expression essential for the growth of colon cancer cells under adherent conditions (Kawasaki et al., 2015).