This resulted in the γ-secretase–mediated cleavage and release of the CD44 intracytoplasmic domain (CD44ICD) that functions as a transcriptional activator of D-type cyclins involving in cell proliferation, and Kruppel-like factor 4 and SRY-box transcription factor 2 (SOX2) expression involved in the pluripotency of cancer stem cells (Figure 2) (Bishnupuri et al., 2022). The gene discussed is SOX2; the disease is cancer.