REG4 and familial pancreatic carcinoma: The key transcriptional factor in the Hedgehog signaling pathway, GLI family zinc finger 1 (GLI1) bound to REG4 promoter regions (GATCATCCA) for its transcription and translation in pancreatic cancer cells, supported by the synergic expression of REG4 and GLI1 (Wang et al., 2011).