The key transcriptional factor in the Hedgehog signaling pathway, GLI family zinc finger 1 (GLI1) bound to REG4 promoter regions (GATCATCCA) for its transcription and translation in pancreatic cancer cells, supported by the synergic expression of REG4 and GLI1 (Wang et al., 2011). This evidence concerns the gene GLI1 and familial pancreatic carcinoma.