He et al. (2012) found that REG4 promoted not only tumor growth but also invasion of pancreatic cancer cells by up-regulating MMP-7 and MMP-9. REG4–overexpressing pancreatic cancer cells were resistant to gemcitabine and γ-radiation (Eguchi et al., 2009). This evidence concerns the gene MMP7 and familial pancreatic carcinoma.