Most of these compounds could relocate and reactivate the tumor suppressor function of p53, resulting in apoptosis or growth arrest in cancer cells (Wadhwa et al., 2000; Wadhwa et al., 2002a; Wadhwa et al., 2006; Widodo et al., 2007b; Lu W. J. et al., 2011; Grover et al., 2012; Nigam et al., 2015; Wadhwa et al., 2016; Bhargava et al., 2018; Radhakrishnan et al., 2021). Here, TP53 is linked to cancer.