TNFSF10 and neoplasm: The apoptosis factor TRAIL is synthesized by immune cells (T- and NK-cells), attaches to the DR4/DR5 cell death receptors on the surface of tumor cells, after which the death-inducing signaling complex (DISC) is formed, which also involves the adapter FAS-associating death domain-containing protein (FADD) and procaspase-8 or -10.