We therefore generated recombinant MeCP2 with the R106 mutated to produce lysine, glutamine, leucine, tryptophan and glycine, thus including the previously explained substitutions for arginine methylated sites (K, Q, and L) and all reported R106 Rett syndrome mutations (W, Q, G, and L). The gene discussed is MECP2; the disease is atypical Rett syndrome.