When autosis is already induced in cardiomyocytes during ischemia/reperfusion, Tat-BECN1 exacerbates myocardial injury (Nah et al., 2020); while administration of Tat-BECN1 prior to ischemia/reperfusion (Nah et al., 2020) or at the time of reperfusion (Xie et al., 2021) reduces cell death and protects cardiac function. Here, TAT is linked to ischemia.