For instance, MRTF-A is upregulated in blood-circulating Mφ associated with atherosclerotic lesions, thus a drug that supplants MRTF-A (Velasquez et al., 2013; Yu-Wai-Man et al., 2017) may inadvertently accelerate atherosclerosis in space. Here, MRTFA is linked to Atherosclerotic lesion.