Extending to biological functions, the epitranscriptome has built its niche in physiological regulation, which is exemplified by circadian rhythm regulation by A-to-I editing catalyzing the ADAR enzyme family (Terajima et al., 2017), GBM-associated protein expression upregulated by METTL3 via SOX2 (Visvanathan et al., 2018), and poor prognostic characterization through the IGF2BP/SOX2/METTL3 axis in CRC (Li et al., 2019b). This evidence concerns the gene SOX2 and colorectal carcinoma.