In cancer, particularly in colorectal cancer, it was evident that ferroptosis promotes metabolic rewiring, or the Warburg effect, which favors cancer cell growth, as well as suppresses ferroptosis sensitivity by inducing ROS production and activating nuclear factor erythroid 2-related factor 2 (NRF2) (Yuan et al., 2021). The gene discussed is NFE2L2; the disease is colorectal cancer.