In a hypopharyngeal squamous cell carcinoma (HPSCC) study by Ye et al. (2020), transcriptomic analyses including m6A-seq, RNA-seq, and RIP-seq identified m6A reader YTHDF1’s downstream target transferrin receptor (TFRC), simultaneously linking to poor prognosis in postoperative platinum-based chemoradiotherapy (CCT) or radiation patients in an m6A-dependent manner. Here, TFRC is linked to hypopharynx squamous cell carcinoma.