We found that the degree of eosinophils and mast cells infiltration in the nasal mucosa and OVA-IgE in the peripheral blood of allergic rhinitis mice were significantly improved after using an IL-9 neutralizing antibody, which confirmed that the IL-9 neutralizing antibody further improved the symptoms of allergic rhinitis by neutralizing IL-9 in the nasal mucosa of mice. The gene discussed is IGHE; the disease is allergic rhinitis.