Tan IIA regulates mitochondrial fission through the JNK/mitochondrial fission factor (MFF) axis, which in turn upregulates mitochondrial pro-apoptotic proteins (Bax and Bad), activates caspase 9, and leads to colon cancer SW837 cell apoptosis (Jieensinue et al., 2018). Here, MFF is linked to colonic neoplasm.