BCL2 and ovarian carcinoma: For example, DHT promotes Keap1-mediated degradation of nuclear factor erythroid 2-related factor 2 (Nrf2) ubiquitination, and it increases the accumulation of ROS, which in turn downregulates Bcl-2, cyclin B1, and Cdc2 levels as well as upregulates Bax levels in ovarian cancer cells in vivo and in vitro (Sun et al., 2022).