BCL2 and ovarian carcinoma: For example, tan IIA induces apoptosis of ovarian cancer A2780 cells by regulating the PI3K/Akt/c-Jun N-terminal kinase (JNK) signaling pathway, which increases the expression of caspase 3, caspase 8, and caspase 9 but decreases the expression of B cell lymphoma 2 (Bcl-2) family proteins (Bcl-w and Bcl-1L) (Zhang et al., 2019a).