Tan IIA regulates mitochondrial fission through the JNK/mitochondrial fission factor (MFF) axis, which in turn upregulates mitochondrial pro-apoptotic proteins (Bax and Bad), activates caspase 9, and leads to colon cancer SW837 cell apoptosis (Jieensinue et al., 2018). This evidence concerns the gene MFF and malignant colon neoplasm.