It has been reported that tan I and tan IIA induce autophagy by inhibiting the PI3K/Akt/mTOR pathway, further inhibiting the proliferation of tumor cells (including ovarian cancer cells, glioma cells, acute promyelocytic leukemia NB4 cells, acute mononuclear leukemia cells, oral squamous cell carcinoma (OSCC) cells, and melanoma cells) (Ding et al., 2017; Li et al., 2017; Qiu et al., 2018; Zhang et al., 2019c; Zhou et al., 2020b; Pan et al., 2021). The gene discussed is AKT1; the disease is melanoma.