Moreover, Sal B induces osteosarcoma MG63 cell apoptosis by increasing the expression of cleaved caspase 3, phosphorylated-p38 mitogen-activated protein kinase (p-p38 MAPK), and phosphorylated-p53 (p-p53) (Zeng et al., 2018). The gene discussed is TP53; the disease is osteosarcoma.