For example, DHT promotes Keap1-mediated degradation of nuclear factor erythroid 2-related factor 2 (Nrf2) ubiquitination, and it increases the accumulation of ROS, which in turn downregulates Bcl-2, cyclin B1, and Cdc2 levels as well as upregulates Bax levels in ovarian cancer cells in vivo and in vitro (Sun et al., 2022). This evidence concerns the gene NFE2L2 and ovarian cancer.