In addition, there is increasing evidence that TNFα/TNFR1-mediated pathways create a pleiotropic microenvironment that plays a critical role in inflammation in the liver, hepatic steatosis, and fibrogenesis and thus in NAFLD progression (Tarrats et al., 2011; Gong et al., 2014). This evidence concerns the gene TNFRSF1A and metabolic dysfunction-associated steatotic liver disease.