For example, microRNA 29c and CD2AP mRNA in urine EVs are related to kidney fibrosis; microRNA-451–5p and WT-1 mRNA are related to diabetes; microRNA-145, microRNA-141, microRNA-196a-5p, microRNA-501–3p, and CDH3 mRNA are related to prostate cancer; microRNA-204–5p is related to kidney cancer; and microRNA-21–5p is related to epithelial cancer (Lv et al., 2013; Lv et al., 2014; Filella and Foj, 2016; Mohan et al., 2016; Royo et al., 2016; Matsuzaki et al., 2017; Rodríguez et al., 2017; Xu et al., 2017; Abe et al., 2018; Kurahashi et al., 2019). This evidence concerns the gene WT1 and diabetes mellitus.