Moreover, we analyzed the downstream signaling pathway involved in ERBB2 gene demethylation and immune activation by assessing the STRING database and comprehensively explored the connections between macrophage-infiltrating immune cells and clinicopathological characteristics, survival outcome, and immunotherapeutic efficacy in cancer therapies, such as tumor proliferation, ECM-related genes, and degradation of ECM. Here, ERBB2 is linked to cancer.