GPT and insomnia measurement: Drug-related AEs included elevated ALT levels (23.1% vs. 25.8%), insomnia (3.8% vs. 3.2%), proteinuria (17.3% vs. 19.4%), ventosity (13.5% vs. 11.8%), hypertension (25% vs. 25.8), hypothyroidism (0% vs. 12.9%) and hand-foot skin reaction (21.2% vs. 22.6%).