Upon stratifying samples by the hormone receptor status of breast tumor, we noted that estrogen receptor (ER)–positive tumor NATs had higher abundance of four genera (Vibrio, Pseudoalteromonas, Photobacterium, and Marinobacterium) and lower abundance of Prevotella_9 compared with ER-negative samples (Figure 3A). Here, NR4A1 is linked to breast neoplasm.