PIK3C3 and neoplasm: For instance, lomitapide, a clinical drug approved by the Food and Drug Administration (FDA) for the treatment of hypercholesterolemia, is recently reported to upregulate AMPK phosphorylation and promote the formation of BECN1-VPS34-ATG14 complex, thereby inducing autophagy in HCT116 and HT29 human CRC cells, which significantly inhibits tumor proliferation in vitro and in vivo (20).