Similarly, Chaetocochin J, an alkaloid monomer derived from Chaetomium sp, activates AMPK and inhibits PI3K-Akt-mTOR to induce autophagy, manifesting a solid antiproliferative effect in RKO, HCT116 and SW480 human CRC cells with IC50s of 0.56, 0.61 and 0.65 μM (34). This evidence concerns the gene AKT1 and colorectal carcinoma.