In CRC, FAT tumor suppressor homolog 4 (FAT4) inhibits the PI3K-Akt-mTOR pathway, promoting autophagy and inhibiting migration and invasion in SW480, HCT116 and LOVO human CRC cells (17); similarly, downregulation of pleckstrin homology like domain family A member 2 (PHLDA2) inhibits the PI3K-Akt-mTOR pathway, inducing autophagy and inhibiting proliferation in SW480, HCT116 human CRC cells (18). Here, PHLDA2 is linked to colorectal carcinoma.