Moreover, lncRNA functional intergenic repeating RNA element (FIRRE) is often located in the nucleus and can bind PTBP1 to promote its translocation to the cytoplasm to stabilize the cytoplasmic mRNA BECN1, increasing the level of autophagy in RKO human CRC cells (51) (Figure 2C). This evidence concerns the gene BECN1 and colorectal carcinoma.