Magnolin, a lignan monomer with anti-inflammatory and antioxidant activity derived from Magnolia biondii, significantly upregulates LC-3B and downregulates p62 by inhibiting leukemia inhibitory factor (LIF)- STAT3-Mcl-1 to induce autophagy in HCT116 and SW480 human CRC cells and HCT116 xenograft model, which showing excellent anticancer potential (36). The gene discussed is LIF; the disease is colorectal carcinoma.