BECN1 and neoplasm: Similarly, flubendazole, an anthelmintic drug approved by FDA, downregulates STAT3 phosphorylation levels, mTOR and p62, and upregulates Beclin 1 and LC3-I/II in HCT116, RKO and SW480 human CRC cells, which promoting the initiation of autophagy to prevent tumor progression without substantially affecting normal cell proliferation (38).