Similarly, flubendazole, an anthelmintic drug approved by FDA, downregulates STAT3 phosphorylation levels, mTOR and p62, and upregulates Beclin 1 and LC3-I/II in HCT116, RKO and SW480 human CRC cells, which promoting the initiation of autophagy to prevent tumor progression without substantially affecting normal cell proliferation (38). This evidence concerns the gene MTOR and neoplasm.