ULK1 and colorectal carcinoma: For instance, Fangchinoline, an alkaloid monomer with anti-inflammatory activity derived from the Stephaniae tetrandrine S. Moore, is a novel autophagy agonist in CRC that activates the AMPK-mTOR-ULK1 pathway to induce autophagy-dependent cell death in HT29 and HCT116 human CRC cells and also exerts an effective growth inhibition of tumors in vivo (33).