Recently, TD-3(TFM)3(FAS), a novel DNA tetrahedron (TD) with two types of therapeutic peptides (FAS peptides and FK-16 peptides) has been designed; among them, FK-16 is delivered to the cytoplasm of HT-29 human CRC cells by cell-penetrating peptide, further upregulating the expression of p53, ATG5, and ATG7, inducing autophagy-dependent cell death and exerting strong and specific tumor-suppressive efficacy (40) (Figure 2B). Here, ATG5 is linked to neoplasm.