For mechanisms of resistance, a study on B-cell lymphoma resistant cells identified upregulation of IL-6, and IL-6 was able to independently activate STAT3 or STAT5 pathways to confer resistance to PI3K inhibition (76), thus the STAT pathway may be a relevant mechanism of resistance for some lymphoproliferative disorders (96). Here, IL6 is linked to B-cell non-Hodgkin lymphoma.