METTL3 and neoplasm: Given that the declining m6A mRNA methylation and increasing translational level of IL-17RA in tumor adjacent tissues, four critical regulators associated with m6A modification including FTO, ALKBH5, METTL14, and METTL3 were examined and results showed FTO, the m6A methyltransferase, was considered as the most important modulator in our study by Western blot.