By observing the expression of COX4I2 in different subtypes of cells, we have a clearer grasp of the location of COX4I2 in pheochromocytoma tissue, which suggests that we need to pay more attention to the interaction of various components in pheochromocytoma microenvironment, rather than the tumor cells themselves. Here, COX4I2 is linked to hereditary pheochromocytoma-paraganglioma.