VWF and neoplasm: In parallel, it has been demonstrated that tumor cell-generated thrombin or tumor cell-secreted VEGF-A can induce endothelial cell transformation into an adhesive and procoagulant surface, through the release of molecules such as interleukin-8, Ang-2, P-selectin and VWF (Bauer et al., 2022[5]; Wagner and Frenette, 2008[74]).