USP2 is a circadian rhythm-related gene that is involved in multiple biological processes, such as pressure overload-induced cardiac remodeling (Xing et al., 2020), breast cancer (He et al., 2019), hemophilia (Xu et al., 2021a), and energy metabolism (Kitamura and Hashimoto, 2021). The gene discussed is ENSG00000279284; the disease is hemophilia.