USP2 is a circadian rhythm-related gene that is involved in multiple biological processes, such as pressure overload-induced cardiac remodeling (Xing et al., 2020), breast cancer (He et al., 2019), hemophilia (Xu et al., 2021a), and energy metabolism (Kitamura and Hashimoto, 2021). Here, ENSG00000280371 is linked to breast carcinoma.