Moreover, they demonstrated that expressions of hST6GalNAc1 gene and sTn is induced by androgen in human prostate cancer cell line LNCaP, and confirmed using ChIP-qPCR that androgen-inducible hST6GalNAc1 gene expression in LNCaP cells is conducted by direct binding of androgen to an androgen receptor-binding site in close proximity to the hST6GalNAc1 promoter (Munkley et al., 2015). Here, AR is linked to Familial prostate cancer.