While there was no significant interaction between time, sex, and treatment in the MOC1 model with regard to CD45+ cells (all leukocytes) in the tongue tissue, we did find a significant effect of treatment [i.e., sham vs. MOC1, F(1,12) = 424.2, p < 0.0001] where there was significantly more CD45+ cell infiltrate in MOC1 tumor bearing mice compared to sham at each timepoint (Figures 5B,C). The gene discussed is PTPRC; the disease is neoplasm.