Our findings demonstrate that IFIT3, IFIT1, and OAS3, and STRING analysis shows that the gene network of IFIT3, IFIT1, IFI44L, OAS3, and LY6E are implicated in seizures during adult epilepsy, which suggests that they may impact the therapeutic efficacy of antiepileptic medicines and may be possible biomarkers for antiepileptic treatment. Here, OAS3 is linked to epilepsy.