We observed that adult patients with epileptic seizures had peripheral whole blood that included miR-654-3p, miR-323a-3p, miR-323b, miR-3283p, miR-342-5p, miR-150-5p, miR-3395p and IFIT3, IFIT1, IFI44L, OAS3, and LY6E in the pathways connected to viral infection. This evidence concerns the gene OAS3 and viral infectious disease.