While SGLT2 seems to be usually upregulated in diabetic kidney disease in man, in our STZ-induced kidney model as well as in many other experimental diabetic disease models renal SGLT2 expression is not upregulated which limits the SGLT2i-mediated increase in urinary glucose levels in diabetic mice (Albertoni Borghese et al., 2009; Vallon et al., 2013). The gene discussed is SLC5A2; the disease is diabetic kidney disease.