For example, isocitrate dehydrogenase 1 (IDH1) is hyperacetylated in CRC primary tumors and liver metastases (181), sirtuin-2 is the deacetylase of IDH1, and SIRT2 overexpression significantly inhibits CRC cell proliferation, migration and invasion (181). This evidence concerns the gene IDH1 and colorectal carcinoma.