The expression of SOX9 is significantly increased in HDAC10-depleted tumor cells, TGFβ pathway-related genes are enriched in HDAC10 knocked out tumor cells, and activation of TGFβ signaling contributes to the induction of SOX9 in HDAC10 knocked out lung adenocarcinoma cells (85). The gene discussed is TGFB1; the disease is neoplasm.